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Cannabidiol, or CBD, is a non-intoxicating component of the cannabis plant with enormous therapeutic potential. Researchers are currently studying the effects of CBD on a wide range of conditions including chronic pain, insomnia, PTSD, anxiety, epilepsy, dementia and more.
Extensive preclinical research and some clinical studies have shown that CBD has strong anti-oxidant, anti-inflammatory, anticonvulsant, anti-depressant, anti-psychotic, anti-tumoral, and neuroprotective qualities.
Source: Fasinu PS, Phillips S, ElSohly MA, Walker LA. Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents. Pharmacotherapy 2016;36(7):781-96.
Campos AC, Fogaça MV, Scarante FF, Joca SRL, Sales AJ, Gomes FV, Sonego AB, Rodrigues NS, Galve-Roperh I, Guimarães FS. Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders. Front Pharmacol. 2017 May 23;8:269.
Cannabinoids (e.g., THC and CBD) are the chemical compounds secreted by cannabis flowers that can affect the human body. They work by imitating compounds our bodies naturally produce, called endocannabinoids, that affect nerve, brain and immune cell activity.
Currently, there are two known primary cannabinoid receptors: CB1 and CB2 receptors. CB1 receptors are located in the central nervous system, and in some peripheral tissues. They affect appetite, muscle control, pain, cognition, thermoregulation, and our stress response. CB2 receptors are primarily found in immune cells, and at a lower density in the central nervous system. CB2 activation is associated with immune function and immune cell proliferation, inflammation, and pain. Although these two cannabinoid receptors have been studied relatively extensively, there are more cannabinoid receptors being examined.
Source: Szaflarski JP, Bebin EM, Cannabis, cannabidiol, and epilepsy--from receptors to clinical response. Epilepsy Behav. 2014;41:277-82
Cannabidiol is one of 85+ cannabinoids found in the cannabis plant, and much of the ongoing research has found it to be a promising potential therapy for many illnesses that medical professionals have previously thought to be untreatable, including:
The Human Body produces Cannabinoids, and CBD Oil can help:
Phytocannabinoids are cannabinoids derived from plants. Endocannabinoids are cannabinoids produced naturally in the human body.
One example of an endocannabinoid is anandamide, or ‘the bliss molecule.’ This molecule activates the CB1 receptor.
Benefits of activating the CB1 receptor include:
• Relieving depression [Source]
• Increasing myelin formation [Source]
• Lowering intestinal inflammation [Source]
• Decreasing intestinal permeability (Leaky Gut Syndrome) [Source]
• Lowering blood pressure [Source]
• Lowering anxiety [Source]
• Reducing fear and paranoia [Source]
• Increasing BDNF levels [Source]
• Increasing PPARy expression [Source]
• Reducing GPR55 signaling [Source]
• Lowering prolactin [Source]
An enzyme in the body known as FAAH is responsible for breaking down anandamide. CBD is an inhibitor of FAAH, meaning more anandamide to be available to the CB1 receptors.
Anandamide has been shown to stop the proliferation of breast cancer cells, promote anti-anxiety and antidepressant effects, and increases neurogenesis. Anandamide plays a role in memory and forgetting, creating a potential natural value for individuals with post traumatic stress disorder (PTSD).
All our products are sold as food supplements only to help promote everyday wellbeing. They are not intended to diagnose, treat, cure or prevent any disease.
Yes, CBD oil is legal in the UK as it is not a controlled substance. There are strict restrictions over its THC content and CBD oil that isn't medically prescribed can only have a maximum THC content of 0.2%.
As the two main ingredients in the cannabis plant, CBD and THC are easily confused. But other than both being called cannabinoids, they are not the same thing. High levels of THC are commonly found in the popular plant but less so in the case of CBD. It makes sense, then, that THC can send you soaring on a high while CBD is reassuringly non-psychoactive.
Unlike THC, the dominant marijuana compound that does cause a high, CBD does not contain the same psychoactive properties. For you, that means the safe and secure use of CBD, able to harness its benefits while being in complete control.
You should speak to your GP or other healthcare professional If you're considering using CBD oil to ensure that it is safe and appropriate for you to do so.
This is particularly important if you have any pre-existing conditions or if you are taking any medications including statins, blood thinning medication and calcium channel blockers.
CBD Oil is only intended for use as a food supplement. Please consult a medical professional if in doubt.
Like some other plant compounds (such as those found in grapefruit, watercress and St John’s Wort) CBD oil may affect the metabolization of certain prescribed medicines. Remember to consult your doctor if you are taking any form of prescribed medication.
The difference is that hemp plants contain no more than 0.3 percent (by dry weight) of THC (tetrahydrocannabinol), the psychoactive substance found in marijuana. By comparison, marijuana typically contains 5 to 20 percent THC. You can't get high on hemp." ... Cannabis plants with more than 0.3 percent THC are marijuana
How can CBD help with so many conditions? It seems too good to be true.
The short answer is Because CBD interacts with and supplements the body's own Endocannabinoid System (ECS) which regulates numerous biological functions.
The primary function of the ECS is to promote balance, or homeostasis, in these systems. Regular use of CBD supplements the ECS and helps keep the body’s ECS receptors and endocannabinoids working at optimal capacity.
CBD is classified as a supplement so we can’t make any medical claims about it or our products. But the animal and human studies showing CBD’s efficacy for a variety of illnesses and diseases are extensive and more are being done every day.
Here at Chill Out Fred we encourage you to do your own research, and to help we have provided some key points and links to some important CBD studies. We will be updating this list as new studies are published so keep coming back to find out how CBD could help you.
“The non-psychoactive phytocannabinoid cannabidiol (CBD) exerts neuroprotective, antioxidant and anti-inflammatory effects and promotes neurogenesis [growth and development of neurons]. CBD also reverses [certain] spatial memory deficits in rodents.” Read the Article
“[Anti-bacterial] activity was exceptional against some of these strains, in particular the multidrug-resistant (MDR) SA-1199B… Also noteworthy is the potent activity demonstrated against [antibiotic resistant bacteria]… These activities compare highly favorably with the standard antibiotics for these strains.” Read the Study
“Cannabinoids, appear to be unaffected by the mechanism that superbugs like MRSA use to evade existing antibiotics… when [researchers] applied extracts from five major cannabinoids to bacterial cultures of six strains of MRSA, they discovered that the cannabinoids were as effective at killing the bugs as vancomycin [a powerful antibiotic that is normally used only as a last resort when other drugs fail] and other antibiotics.” Read the Article
A 2015 analysis of previous studies concluded that CBD oil is a promising treatment for numerous forms of anxiety, including social anxiety disorder, panic disorder, obsessive-compulsive disorder, generalized anxiety disorder, and post-traumatic stress disorder. Read the Article
“Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Moreover, CBD was shown to reduce anxiety in patients with social anxiety disorder.” Read the Study
“CBD could reduce symptoms of social anxiety in people with social anxiety disorder. Brain scans of participants revealed changes in blood flow to the regions of the brain linked to feelings of anxiety. In this study, cannabidiol not only made participants feel better but also changed the way their brains responded to anxiety.” Read the Article
Arthritis / Joint Pain:
“These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.” Read the Article
“The analgesic ability of cannabinoids may provide a much-needed alternative to opioids.” Read the Article
Bone Growth / Healing:
“CBD stimulates bone-building cells to express the genes involved in producing the primary enzyme involved in bone healing. Genetics don’t lie! … It was also determined… that CBD significantly enhanced the mechanical properties and strength of the bone after 8 weeks.”
Read the Article
“This study demonstrates that CBD is cardio-protective in the acute phase of myocardial ischaemia and reperfusion [restricted blood flow to the heart and re-oxygenation of blood] by both reducing ventricular arythmias and attenuating infarct [dead tissue] size.” Read the Article
“In blood, CBD influences the survival and death of white blood cells, white blood cell migration and platelet aggregation. Taken together, these preclinical data appear to support a positive role for CBD treatment in the heart, and in peripheral and cerebral vasculature.” Read the Article
“Cannabidiol (CBD) [has] great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like [anti-anxiety] compound.” Read More
“A growing body of evidence unequivocally demonstrates that deficits in endocannabinoid signalling may result in depressive and anxiogenic [anxiety inducing] behavioral responses.” Read the Study
“A 2016 study suggested that a lack of endocannabinoids — neurotransmitters that bind to cannabinoid receptors — may be at the root of chronic pain syndromes, including migraines and fibromyalgia. Taking CBD may correct this deficiency, explaining the compound’s success in alleviating chronic pain.” Read the Article
“Research from the targeted use of cannabinoids for the purpose of boosting the immune system is overwhelmingly positive. According to new research, cannabinoids may have an important balancing role that allows the immune system to function at maximum efficiency. Cannabinoids have been shown to interact with the ECS in a way that helps promote maximum immune function and optimal health through various stages of life.” Read More
In a review of studies regarding the involvement of cannabinoids in the process of inflammation the authors conclude that: “A possible mechanism for these actions is suggested involving increased production of eicosanoids that promote the resolution of inflammation.” Read More
Irritable Bowel Syndrome:
“CBD is a very promising compound since it shares the typical cannabinoid beneficial effects on [the] gut, lacking any psychotropic effects… it is evident that this compound may interact at extra-cannabinoid system receptor sites… This strategic interaction makes CBD a potential candidate for the development of a new class of anti-IBD drugs.” Read the Article
“Together, our findings highlight the anti-inflammatory effects of CBD in this viral model of MS and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component.” Read More
“Preclinical research indicates that cannabinioids, including CBD, may be effective clinically for treating both nausea and vomiting produced by chemotherapy or other therapeutic treatments.” Read the Study
“CBD significantly suppresses chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance.These cannabinoids [CBD] may represent a novel class of therapeutic agents for the treatment of chronic pain and other diseases involving glycine receptor dysfunction.” Read the Study
“Cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions.” Read More
“Our results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.” Read the Study
Sleep / Insomnia:
“CBD has the ability to reduce anxiety, which can be helpful in reducing sleep difficulties and improving sleep quality. CBD may increase overall sleep amounts, and improve insomnia, according to research. CBD has been shown to reduce insomnia in people who suffer from chronic pain. In smaller doses, CBD stimulates alertness and reduces daytime sleepiness, which is important for daytime performance and for the strength and consistency of the sleep-wake cycle.” Read the Article
“Placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by ~40% during treatment. Results also indicated some maintenance of this effect at follow-up… The reduction in smoking observed in this study was striking and occurred in the absence of other specific effects, notably on craving. Given the pivotal role of craving in relapse, this is a potentially very encouraging finding, in that participants using the CBD inhaler reduced the number of cigarettes they smoked without increased craving for nicotine.” Read the Study